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Target intelligence / Profile preview
Inhibitor of nuclear factor kappa B alpha (IκBα)
- Target
- IκBα
- Molecular classification
- Inhibitory protein, Cytosolic protein
01
Overview
IκBα is a cytoplasmic protein that inhibits the activity of the NF-κB transcription factor by masking its nuclear localization signal and preventing its entry into the nucleus. The IKK complex phosphorylates IκBα, leading to its degradation and releasing NF-κB for nuclear translocation and gene expression. This pathway is crucial for immune responses, inflammation, and cell survival.
- Other names
- Inhibitor of NF-κB alphaIκB alphaNFKBIA
02
Mechanism of action
For drugs that indirectly affect IκBα, mechanisms typically involve modulating the NF-κB signaling pathway, either by inhibiting the breakdown of IκBα or by directly inhibiting the NF-κB transcription factor.
03
Biological functions
Signal transductionImmune responseCell survivalInflammation regulation
04
Disease associations
CancerInflammationAutoimmune diseasesInfection
05
Safety considerations
Broader impact on the immune systemPotential side effects from modulating NF-κB activity
06
Interacting drugs
Glucocorticoids
1 more in the full profile.
07
Biomarkers
NF-κB signaling biomarkersNF-κB subunit expressionNF-κB activity
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