Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha (IKKα)
- Target
- IKKα
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
The inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKα) is a serine/threonine protein kinase that plays a central role in the regulation of the NF-κB signaling pathway. This pathway is crucial for immune response, inflammation, cell survival, and development. IKKα forms part of the IκB kinase (IKK) complex along with IKKβ and NEMO. It is essential for activating NF-κB by phosphorylating IκBs. Dysregulation or mutation affecting IKKα contributes to chronic inflammation and cancer development. As such, IKKα is considered an attractive target for pharmacological intervention against inflammatory diseases and cancers.
- Other names
- I-kappa-B kinase alphaIKK-AIKK-alphaIkBKAIkappaB kinase alpha/1/IKK1/NFKBIKA/TCF-16Conserved helix-loop-helix ubiquitous kinaseTranscription factor 16CHUK
02
Mechanism of action
Phosphorylation of IκBs, activation of NF-κB pathway
03
Biological functions
Signal transductionImmune responseInflammationCell survivalDevelopmentRegulation of NF-κB signaling pathwayHistone modification
04
Disease associations
CancerInflammation
05
Safety considerations
Potential for broad immunosuppressionOff-target effects on other kinases
Beyond the preview
Go deeper on Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha (IKKα).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha (IKKα).