Inhibitory neurotransmission in central nervous system

Inhibitory neurotransmission in central nervous system" is not a specific molecule, receptor, or protein but rather describes a physiological process involving multiple molecular players. The main inhibitory neurotransmitters mediating this process are **gamma‑aminobutyric acid** (GABA) and **glycine**, which act through their respective receptors—GABA-A, GABA-B, and glycine receptors—to hyperpolarize postsynaptic neurons and reduce the likelihood of action potential generation[1][2][3]. This inhibitory signaling is essential for balancing excitatory input within the brain and spinal cord, regulating functions such as behavior, motor control, mood, sleep, and more[2]. Dysfunction in inhibitory neurotransmission is implicated in various neurological and psychiatric diseases. However, "inhibitory neurotransmission" itself does not refer to a single druggable target but rather to an entire class of mechanisms involving several distinct molecular targets. --- **Notes:** The entry "Inhibitory neurotransmission in central nervous system" is too broad for structured target annotation. It refers to a physiological mechanism mediated by multiple molecules—primarily GABAergic and glycinergic systems—not a single canonical entity suitable for drug targeting or biomarker development[1][2]. For structured data purposes such as drug interaction or mechanism-of-action mapping, it would be necessary to specify individual components like "Gamma‑aminobutyric acid receptor subunit alpha‑1" or "Glycine receptor subunit alpha‑1".

Other names

Inhibitory neurotransmissionInhibitory neurotransmitters in CNSGABAergic transmission (context-dependent)Glycinergic transmission (context-dependent)