Innate immune pathway target

Innate immune pathway targets represent a broad class of molecules involved in the body's first line of defense against pathogens and cellular stress. These targets primarily include pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs), NOD-like receptors (NLRs, e.g., NLRP3), and the cGAS-STING pathway, which sense pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) [1, 2]. Activation of these pathways leads to the production of pro-inflammatory cytokines, interferons, and the assembly of inflammasomes, which are critical for initiating an immune response [1]. In disease contexts, dysregulation of these pathways can lead to chronic inflammation, autoimmune disorders, or immune evasion by tumors [1, 2]. Therapeutic strategies include agonists to stimulate anti-tumor immunity or vaccine responses, and antagonists or degraders to treat inflammatory and autoimmune conditions [1, 2].

Other names

Innate immune sensorPattern recognition receptorPRRInnate immune signaling molecule

Modulation (activation or inhibition) of pattern recognition receptors and downstream signaling molecules to regulate the innate immune response.