Innate Immune System Activation via Saponin-Based Adjuvant (N/A)

Saponin-based adjuvants are a class of immunostimulatory compounds that activate the innate immune system to promote robust adaptive immune responses against co-administered antigens. They enhance antigen presentation, induce cytokine production, and recruit effector leukocytes, leading to strong antibody and cytotoxic T cell responses. Their modularity allows combination with other adjuvants for tailored vaccine design. The activity profile depends on the aglycone core type, sugar chain branching and presence or absence of acyl residues, which affect both potency and toxicity profiles.

Other names

Saponin adjuvant activitySaponin-mediated immune stimulationQS-21 adjuvant activity

Enhances antigen presentation/cross-presentation by DCs; induces cytokines; recruits effector leukocytes