Innate immune system and local tissue matrix

The "Innate immune system and local tissue matrix" refers to the complex functional interface between innate immune cells and the extracellular matrix (ECM). This is not a single molecular target but a biological environment where cells like macrophages and neutrophils interact with structural proteins like collagen and elastin [1]. The ECM acts as a reservoir for cytokines and growth factors, while its degradation products can act as signaling molecules [2]. In pathological conditions such as cancer or chronic fibrosis, the remodeling of this matrix releases damage-associated molecular patterns (DAMPs) that trigger innate immune receptors [3]. These interactions are crucial for regulating inflammation, wound healing, and the structural integrity of tissues [4]. Therapeutic interventions typically target specific components within this system, such as matrix metalloproteinases (MMPs) or integrins, to modulate the immune response [5]. Understanding this axis is essential for developing therapies that address the tumor microenvironment and fibroinflammatory diseases [6]. Consequently, while the system as a whole is a broad physiological context, it serves as a framework for identifying specific druggable receptors and enzymes [7].

Other names

ECM-immune interfaceExtracellular matrix and innate immunityImmune-matrix niche

Inhibition of matrix remodeling, modulation of immune cell adhesion, and blockade of DAMP-mediated signaling.