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Target intelligence / Profile preview
INO80 antisense RNA 1 (INO80-AS1)
- Target
- INO80-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
INO80 antisense RNA 1 (INO80-AS1) is a long non-coding RNA transcribed from the INO80 gene locus in antisense orientation. It does not encode a protein and is believed to function in gene regulation, possibly through interactions with chromatin remodeling complexes like the INO80 complex. Long non-coding RNAs such as INO80-AS1 may modulate gene expression by binding to protein complexes and guiding their activity or localization, thereby influencing transcriptional networks. The specific biological and clinical functions of INO80-AS1 have not been thoroughly characterized, but the broader INO80 chromatin remodeler is associated with diverse processes such as DNA repair, transcription regulation, and cancer progression. INO80-AS1 has not been directly implicated as a therapeutic target or biomarker in current biomedical literature.
- Other names
- INO80-AS1ENST00000560178
02
Mechanism of action
Not applicable; no drugs targeting this lncRNA are described
03
Biological functions
Gene regulationmodulation of chromatin remodeling complexes through lncRNA-protein interactionspossibly involved in transcriptional regulation by interacting with chromatin remodelers such as INO80
04
Disease associations
Potential involvement in cancer (based on the association of INO80 complex dysregulation with cancer stem cell maintenance and progression, but no direct evidence for INO80-AS1 itself so far)
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