INO80 complex subunit B (INO80B)

INO80 complex subunit B (INO80B) is a protein subunit of the large ATP-dependent INO80 chromatin remodeling complex. The INO80 complex, found in humans and conserved from yeast to mammals, features over 15 subunits and promotes alterations to chromatin structure that are critical for DNA accessibility and expression. The complex includes modules responsible for ATP hydrolysis, nucleosome movement, and recognition of histone and DNA features. INO80B is specifically a conserved accessory subunit present in the core remodeling module, contributing to nucleosome binding and remodeling activity. Although INO80 complex activity has implications in genome stability, DNA repair, and transcriptional regulation, INO80B itself is not a direct therapeutic drug target, and no pharmacological modulators are known for this protein. It is more accurately considered a structural and regulatory factor within the chromatin remodeling machinery[1][2][3][4].

Other names

HMGA1L4PAPA1ZNHIT4hIes2PAPA-1HMGIYL4PAP-1BPIES2High mobility group AT-hook 1-like 4IES2 homologZinc finger HIT domain-containing protein 4PAP-1-associated protein 1PAP-1 binding proteinIES2 homolog (S. cerevisiae)PAP (Pim-1 associated protein) associated protein 1Zinc finger, HIT type 4

Not applicable (No drugs currently target this subunit; however, nucleosome positioning and chromatin remodeling is the result of ATP hydrolysis and action of the entire INO80 complex[2][3][4].)