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INO80 complex subunit C (INO80C)
- Target
- INO80C
- Molecular classification
- Chromatin remodeling complex subunit, Nuclear protein, Other (not a receptor, enzyme, transporter; belongs to chromatin remodeling families)
01
Overview
INO80 complex subunit C is a proposed core structural and functional component of the INO80 chromatin remodeling complex, which is required for transcription, DNA replication, and DNA repair[3][4]. This multisubunit complex modulates chromatin structure and plays a critical role in genome stability, proper chromosome segregation, and the prevention of polyploidy[2]. INO80C, also known as IES6 or C18orf37, interacts with other subunits to form a large nucleoprotein complex. Loss or mutation of INO80C disrupts chromatin structure near centromeres, causes missegregation of chromosomes, and leads to genome instability—a feature relevant for cancer biology[2]. No drugs directly target INO80C, nor is it currently used as a clinical biomarker, but its function is fundamental to cellular genomic maintenance[2][3][7].
- Other names
- INO80 complex subunit CINO80CC18orf37hIes6FLJ38183IES6IES6 homologIES6 homolog (S. cerevisiae)
02
Mechanism of action
null
03
Biological functions
Chromatin remodelingTranscriptional regulationDNA replicationDNA repairGenome stability and chromosome segregation
04
Disease associations
Cancer (via genome instability and ploidy changes)Other (general genetic instability)
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