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Inorganic Polyphosphate (polyP)

Target: polyP
Molecular classification: Other

Overview

Inorganic polyphosphate (polyP) is a linear polymer composed of orthophosphate residues linked by high-energy phosphoanhydride bonds. Synthesized enzymatically from ATP, it plays diverse roles in cellular metabolism, stress response, energy storage, and signaling. It is an emerging therapeutic target for disorders involving thrombosis or dysregulated inflammation/complement activation due to its role in coagulation and immunity.

Other names: PolyphosphatePoly PInorganic Polyphosphate (polyP)

Mechanism of action

Modulation of coagulation cascades and innate immune responses

Biological functions

Energy storageMetabolismBlood coagulation modulationImmune regulationRegulation of gene expressionStress responsemTOR signaling regulationCellular proliferation controlLysosomal function

Disease associations

ThrombosisDysregulated inflammationInfection

Safety considerations

Potential for dysregulation of coagulationPotential for unintended immune modulation

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