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Target intelligence / Profile preview
Inosine Monophosphate Dehydrogenase (IMPDH)
- Target
- IMPDH
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo biosynthesis of guanine nucleotides. It catalyzes the rate-limiting step: the conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), with concomitant reduction of NAD+ to NADH. This reaction is essential for maintaining adequate pools of guanine nucleotides, which are critical for DNA and RNA synthesis, signal transduction, and energy transfer. IMPDH is an established drug target for immunosuppressive, anticancer, and antiviral therapies. Inhibitors targeting this enzyme disrupt guanine nucleotide synthesis, thereby affecting rapidly dividing cells such as lymphocytes or cancer cells.
- Other names
- IMPDIMPD1LCA11RP10
02
Mechanism of action
Inhibition of guanine nucleotide synthesis
03
Biological functions
Nucleotide biosynthesisCell proliferationDNA synthesisRNA synthesisSignal transductionEnergy transferRegulation of guanine nucleotide pools
04
Disease associations
Retinitis pigmentosa type 10CancerViral infectionsAutoimmune disorders
05
Safety considerations
ImmunosuppressionPotential for off-target effects due to nucleic acid binding
06
Interacting drugs
Mycophenolic acid derivatives
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