Inosine monophosphate dehydrogenase 1 pseudogene 3 (IMPDH1P3)

IMPDH1P3 is classified as a pseudogene version of the IMPDH1 gene, located in the human genome but not known to encode a functional protein. Pseudogenes typically arise from gene duplication or retrotransposition events and subsequently lose the ability to produce a functional protein due to accumulating mutations. IMPDH1P3 does not contribute directly to cellular enzyme activity, purine metabolism, or disease processes reported for its functional counterpart IMPDH1. There is no evidence that IMPDH1P3 produces a protein, acts as a therapeutic target (enzyme, receptor, transporter, etc.), or is involved in drug response or pathology[7]. Key Points: - IMPDH1P3 is not an active gene; it is a nonfunctional pseudogene, distinct from the protein-coding IMPDH1 gene[7]. - IMPDH1 (not the pseudogene) is the druggable target for agents like mycophenolic acid and is involved in purine metabolism, immune regulation, and certain disease processes[4][6]. - No biological, pharmacological, or clinical role is ascribed to IMPDH1P3 itself in the current literature or genomic databases[7]. - If the intended target was the functional gene (Inosine monophosphate dehydrogenase 1, or IMPDH1), a different entry with substantial information on enzyme function, molecular classification (enzyme), and disease involvement would be appropriate[3][4][6]. In summary, IMPDH1P3 is properly annotated as a genomically located pseudogene not involved in enzymatic or therapeutic processes and is not considered a druggable or functional target[7]. If the original query sought an active purine metabolism enzyme or therapeutic target, refer to IMPDH1 instead.

Other names

IMPDH1 pseudogene 3