Inosine monophosphate dehydrogenase 1 pseudogene 7 (IMPDH1P7)

Inosine monophosphate dehydrogenase 1 pseudogene 7 (IMPDH1P7) is a genomic sequence that closely resembles the coding gene IMPDH1 but contains mutations or deletions rendering it incapable of producing a functional inosine monophosphate dehydrogenase enzyme. Pseudogenes like IMPDH1P7 arise from gene duplication or retrotransposition events, and although they may retain sequence similarity to their parent genes, they do not actively participate in cellular biochemical pathways nor serve as drug targets. While the functional gene (IMPDH1) is crucial for purine biosynthesis and can be implicated in inherited disease such as retinal degeneration[8][9], the pseudogene IMPDH1P7 has no documented biological activity and is not relevant to therapeutic targeting[3]. If the query intends a protein target or receptor for drug development, IMPDH1P7 is not suitable; the correct target would be the functional protein "Inosine monophosphate dehydrogenase 1" (IMPDH1), which is an established therapeutic enzyme, but not its pseudogene relatives[2][5].

Other names

NCBI gene ID 391467