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Target intelligence / Profile preview
Inosine Monophosphate Dehydrogenase Type I (IMPDH1)
- Target
- IMPDH1
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Inosine Monophosphate Dehydrogenase Type I (IMPDH1) is an enzyme that catalyzes the conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), the first committed step in de novo guanine nucleotide synthesis. It exists as a homotetramer and plays a crucial role in DNA and RNA synthesis, signal transduction, energy transfer, and cell growth regulation. Defects in IMPDH1 are associated with retinitis pigmentosa type 10 (RP10). Inhibitors like mycophenolic acid and VX-497 are explored for immunosuppression and antiviral therapies.
- Other names
- IMPDIMPD1IMPDH-ILCA11RP10sWSS2608
02
Mechanism of action
Inhibition of IMPDH1, leading to decreased guanine nucleotide synthesis
03
Biological functions
DNA synthesisRNA synthesisSignal transductionEnergy transferCell growth regulationGuanine nucleotide biosynthesis
04
Disease associations
Retinitis pigmentosa type 10 (RP10)
05
Interacting drugs
Mycophenolic acid (MPA)
1 more in the full profile.
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