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Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2)
- Target
- ITPRIPL2
- Molecular classification
- Protein-coding gene, Predicted membrane protein, DANGER family member, Other (not currently classified as receptor, ion channel, transporter, enzyme, transcription factor, or histone modifier according to current data)
01
Overview
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2 (ITPRIPL2) is a predicted protein-coding gene localized in the membrane with little characterized direct function. ITPRIPL2 is subject to post-transcriptional regulation by microRNAs, and its transcript levels are inversely correlated with several microRNAs implicated in breast cancer prognosis. It is a member of the DANGER protein family, with disease associations that include breast cancer (as a prognostic marker) and Diamond-Blackfan anemia 4, as listed in some gene databases. The full range of its molecular functions and physiological roles remains to be elucidated, although it is flagged for further study as a possible participant in oncogenic pathways. Fusion events involving ITPRIPL2 are observed in multiple cancer types, hinting at possible relevance in genomic instability and tumorigenesis.
- Other names
- ITPRIPL2ITPRIP like 2IPIL2FLJ22994MGC126798MGC126800LOC162073D1CC130081G24E030018N11RikRGD1564255
02
Mechanism of action
Not established. No mechanism of action for direct drug targeting of ITPRIPL2 has been reported to date.
03
Biological functions
Putative transcriptional regulation (may function as a transcriptional repressor in fusion protein context)Possible involvement in post-transcriptional regulation, especially in microRNA-mediated pathwaysPotential roles in membrane-associated cellular processesBiological functions remain largely uncharacterized, inferred mostly from association studies
04
Disease associations
Cancer (breast cancer: microRNA-mRNA regulatory signatures associate ITPRIPL2 with patient survival)Possible involvement in Diamond-Blackfan anemia 4 (as per gene-disease association)Observed in pan-cancer gene fusion datasets
05
Biomarkers
Prognostic marker in breast cancer: ITPRIPL2 mRNA levels are inversely correlated with microRNAs, associated with patient survivalNo established predictive, monitoring, or companion diagnostics biomarkers
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