Inositol hexakisphosphate kinase 2 (IP6K2)

Inositol hexakisphosphate kinase 2 (IP6K2) is an intracellular enzyme that phosphorylates inositol hexakisphosphate (InsP6) to produce inositol pyrophosphates, notably diphosphoinositol pentakisphosphate (InsP7)[6]. IP6K2 plays critical roles in diverse biological processes, including energy homeostasis, apoptosis, mitochondrial function, neuroprotection, and regulation of cellular signaling. It is distinct for its regulatory effects on mitochondria, influencing cellular responses to metabolic and oxidative stress, and modulates both catalytic (kinase-dependent) and non-catalytic (structural or signaling) functions such as mitophagy and Hedgehog pathway activity[1][2][3][5][6]. Dysregulation of IP6K2 has been implicated in cancer, neurodegenerative diseases, and mitochondrial disorders, marking it as a relevant therapeutic and biological target[2][3][5].

Other names

Inositol hexakisphosphate kinase 2IP6K2IHPK2TCCCIA00113InsP6 kinase 2InsP6K2PiUSP(i)-uptake stimulatorATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulatorPIUS

Enzymatic inhibition (e.g. by TNP)[5]; Neuroprotection via restoration of mitochondrial/energy homeostasis (e.g. by NAC)[1][2]