Target intelligence / Profile preview

Inositol Monophosphatase (None)

Target: None
Molecular classification: Enzyme, Phosphatase

Overview

Inositol monophosphatase (IMPase) is a crucial enzyme involved in the regulation of intracellular myo-inositol levels, which are essential for the synthesis of phosphatidylinositol and various inositol phosphate signaling molecules. It catalyzes the dephosphorylation of inositol monophosphate to produce free myo-inositol and inorganic phosphate. It is a homodimer with an active site containing metal binding sites. IMPase is a drug target for psychiatric disorders like bipolar disorder, with lithium acting as an inhibitor.

Mechanism of action

Lithium inhibits IMPase activity, thereby modulating signaling pathways associated with mood stabilization.

Biological functions

Regulation of intracellular myo-inositol levelsPhosphatidylinositol signaling pathwayDe novo inositol biosynthesisSignal transduction

Disease associations

Bipolar disorderTriple-negative breast cancerCognitive dysfunction

Safety considerations

Lithium toxicity

Interacting drugs

Lithium

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