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Inositol Phosphorylceramide Synthase (IPC synthase)

Target: IPC synthase
Molecular classification: Enzyme, Transferase

Overview

Inositol phosphorylceramide synthase (IPC synthase) is an enzyme that catalyzes the formation of inositol phosphorylceramide (IPC) from ceramide and phosphatidylinositol. It is essential for sphingolipid biosynthesis in fungi, plants, and some protozoa, but is absent from mammals, making it a promising target for antifungal drug development. Inhibitors of IPC synthase include aureobasidin A, rustmicin, galbonolide A, and khafrefungin.

Other names: Inositol phosphoceramide synthaseAUR1 (in yeast)

Mechanism of action

Inhibition of IPC synthase activity

Biological functions

Inositol phosphoceramide metabolic processSphingolipid biosynthesisLipid metabolism

Disease associations

Infection

Safety considerations

Species-specific sensitivity to inhibitorsPotential for off-target effects in organisms possessing IPC synthase (e.g., plants, protozoa)

Interacting drugs

Aureobasidin A

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