Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Inositol polyphosphate-4-phosphatase type I A (INPP4A)
- Target
- INPP4A
- Molecular classification
- Enzyme, Phosphatase
01
Overview
Inositol polyphosphate-4-phosphatase type I A (INPP4A) is an Mg²⁺-independent enzyme that catalyzes the removal of the phosphate group from the 4-position of the inositol ring in phosphatidylinositol 3,4-bisphosphate and related substrates, antagonizing the PI3K-AKT/PKB signaling pathway. It plays an important modulatory role in cell cycle progression, cell survival, and neuronal functions, with disease relevance in neurodegeneration and cancer[1][2][3].
- Other names
- INPP4AInositol polyphosphate 4-phosphatase type IType I inositol 3,4-bisphosphate 4-phosphataseINPP4TVAS1Inositol polyphosphate-4-phosphatase, type I, 107kDaEC 3.1.3.66[1]
02
Mechanism of action
Hydrolysis of the 4-phosphate from phosphatidylinositol 3,4-bisphosphate, counteracting PI3K signaling, thereby negatively regulating Akt (protein kinase B) activity[1][2]
03
Biological functions
Signal transductionRegulation of the PI3K-AKT signaling pathwayModulation of cell cycle progression and cell survivalRegulation of synaptic localization of NMDA receptors
04
Disease associations
Neurodegenerative diseaseCancerOther (e.g., Dyskeratosis congenita)[1][2]
05
Safety considerations
Potential for neurodegeneration with loss-of-function mutationsPotential effects on cell survival and proliferation leading to tumorigenesis if dysregulated[2]
Beyond the preview
Go deeper on Inositol polyphosphate-4-phosphatase type I A (INPP4A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Inositol polyphosphate-4-phosphatase type I A (INPP4A).