Inositol polyphosphate-5-phosphatase F (INPP5F)

Inositol polyphosphate-5-phosphatase F (INPP5F) is a large membrane-associated enzyme (128 kDa, 1132 amino acids) containing a Sac domain and is primarily responsible for dephosphorylating specific phosphoinositides, particularly phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. These actions position it as a modulator of key cellular processes such as endocytic recycling, cell migration, signal transduction, and STAT3/AKT pathway regulation. INPP5F plays roles in cardiac physiology, neural regeneration, and has implications for cancer biology and other diseases. No directly interacting drugs are listed in pharmacogenomic resources. As an enzyme modifying phosphoinositide signaling, it shares molecular relationships with OCRL and other Sac domain phosphatases, distinguishing its function from related phosphatases in cellular homeostasis and disease[1][2][3][4][5].

Other names

SAC2KIAA0966hSAC2Phosphatidylinositide phosphatase SAC2Sac domain-containing inositol phosphatase 2Sac domain-containing phosphoinositide 4-phosphatase 2Sac domain-containing phosphoinositide 5-phosphatase 2MSTP007MSTP047

Dephosphorylation of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate at the 5-position, impacting downstream PI3K/AKT and STAT3 pathways