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Target intelligence / Profile preview
Inositol Trisphosphate Receptor (IP3R)
- Target
- IP3R
- Molecular classification
- Ion channel, Receptor
01
Overview
The inositol trisphosphate receptor (IP3R) is a calcium channel primarily located on the endoplasmic reticulum membrane. It is activated by the binding of inositol 1,4,5-trisphosphate (IP3), leading to the release of calcium ions into the cytosol. This calcium release initiates various downstream cellular responses. The functional channel is a tetramer formed by four identical subunits. There are three main isoforms encoded by ITPR1, ITPR2, and ITPR3. IP3Rs play a critical role in signal transduction, metabolism, cell proliferation, and other physiological processes. Disruption of this pathway has been implicated in several diseases.
- Other names
- InsP3RITPR
02
Mechanism of action
Modulation of IP3R activity
03
Biological functions
Signal transductionCalcium signalingSecretionMetabolismCell proliferationFertilizationMuscle contraction/relaxation
04
Disease associations
Neurodegenerative diseaseAlzheimer's disease
05
Safety considerations
Dysregulation implicated in several diseases
06
Interacting drugs
Lithium
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