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Target intelligence / Profile preview
Inositol Trisphosphate Receptor (Endoplasmic Reticulum) (IP3R)
- Target
- IP3R
- Molecular classification
- Receptor, Ion channel, Ligand-gated ion channel
01
Overview
The inositol trisphosphate receptor (IP3R) is a calcium (Ca²⁺) channel located primarily on the endoplasmic reticulum (ER) of animal cells. It is activated by binding to inositol 1,4,5-trisphosphate (IP3), a second messenger. Upon activation, IP3Rs mediate the release of Ca²⁺ from ER stores into the cytosol, initiating and regulating diverse cellular processes.
- Other names
- IP₃ receptorInsP₃ receptorInsP₃RInositol 1,4,5-trisphosphate receptor
02
Mechanism of action
IP3 binding triggers channel opening and Ca²⁺ release from ER stores into the cytosol.
03
Biological functions
Calcium signalingSignal transductionRegulation of intracellular calcium dynamicsCell division/proliferationApoptosisFertilization/developmentSecretionNeuronal signalingLearning and memory
04
Disease associations
Neurological disordersImmune disordersCardiac diseasesCancer
05
Safety considerations
Dysregulation can lead to various diseases.Potential for off-target effects due to ubiquitous expression.Complex regulation and interactions make targeted drug development challenging.
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