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Target intelligence / Profile preview
Voltage-gated sodium channel (insect) (VGSC)
- Target
- VGSC
- Molecular classification
- Ion channel, Voltage-gated ion channel, Sodium channel
01
Overview
The insect voltage-gated sodium channel (VGSC) is a transmembrane protein essential for the generation and propagation of action potentials in the nervous system of insects. It is the primary molecular target for several major classes of insecticides, including DDT, pyrethroids, and sodium channel blocker insecticides (SCBIs). Insects typically possess a single VGSC gene that can produce multiple splice variants through alternative exon usage.
- Other names
- Insect voltage-gated sodium channelInsect VGSC
02
Mechanism of action
Pyrethroids and DDT: Bind to open channels, stabilizing them in an open state, causing prolonged sodium currents. SCBIs: Bind to the inactivated state of the channel, blocking ion flow.
03
Biological functions
Action potential initiationAction potential propagationNeuronal signaling
04
Disease associations
Pest controlVector controlInsecticide resistance
05
Safety considerations
Insecticide resistance (kdr mutations)Potential off-target effects of insecticides
06
Interacting drugs
Pyrethroids
2 more in the full profile.
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