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Target intelligence / Profile preview
Insulin B chain (9-23) Epitope-Specific T Cell Receptor (InsB:9-23 TCR)
- Target
- InsB:9-23 TCR
- Molecular classification
- T Cell Receptor, αβ-TCR, Receptor
01
Overview
The insulin B chain (9-23) epitope-specific T cell receptor (TCR) is a TCR that specifically recognizes the 9-23 amino acid sequence of the insulin B chain. This epitope is a dominant autoantigen in type 1 diabetes, particularly in the non-obese diabetic (NOD) mouse model and in humans. T cells bearing these receptors play a central role in initiating and propagating autoimmune responses against pancreatic beta cells, leading to their destruction and subsequent development of type 1 diabetes.
- Other names
- Insulin B chain 9-23 TCRBDC12-4.1 TCRInsulin B:9-23-reactive TCRAnti-Insulin-B:9-23 TCR
02
Mechanism of action
T cell activation and immune response modulation
03
Biological functions
Antigen recognitionT cell activationImmune responseAutoimmune responseT cell signaling
04
Disease associations
Type 1 diabetesAutoimmunityInsulitis
05
Safety considerations
Generalized immunosuppressionOff-target effects due to TCR cross-reactivityCytokine release syndromeExacerbation of autoimmunity (in some contexts)
06
Biomarkers
TCR Vα and Vβ chain usageCD4+ T cell frequencyCytokine production (e.g., IFN-γ, IL-17)TCR avidity for Insulin B:9-23/MHC complex
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