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Target intelligence / Profile preview
Insulin-Degrading Enzyme (IDE)
- Target
- IDE
- Molecular classification
- Enzyme, Metalloprotease, M16 metalloprotease family
01
Overview
Insulin-degrading enzyme (IDE), also known as insulysin or insulin protease, is a zinc-binding metalloprotease that plays a central role in the degradation of insulin and several other bioactive peptides, including amyloid-β (Aβ). It is essential for regulating peptide hormone signaling cascades and maintaining blood glucose homeostasis. Genetic studies link IDE variants to type 2 diabetes mellitus susceptibility and Alzheimer's disease pathogenesis.
- Other names
- InsulysinInsulin protease
02
Mechanism of action
Proteolytic degradation of target peptides
03
Biological functions
Insulin degradationAmyloid-beta degradationPeptide hormone regulationAntigen processingViral entry receptor
04
Disease associations
Type 2 Diabetes MellitusAlzheimer's DiseaseHyperinsulinemiaPostprandial hyperglycemia
05
Safety considerations
Modulating IDE activity may have off-target effects due to its broad substrate specificity.
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