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Target intelligence / Profile preview
Insulin-like Growth Factor 1 (IGF1)
- Target
- IGF1
- Molecular classification
- Peptidic hormone, Growth factor
01
Overview
Insulin-like growth factor 1 (IGF-1) is a protein that acts as the main mediator of growth hormone (GH) effects. It stimulates systemic body growth, particularly in skeletal muscle, cartilage, and bone. IGF-1 exerts its biological actions primarily by binding to the type I insulin-like growth factor receptor (IGF-1R), activating intracellular signaling cascades. It is essential for fetal development and maintains tissue homeostasis in adults. Dysregulation is associated with diseases like cancer and muscle disorders.
- Other names
- IGF-1Somatomedin C
02
Mechanism of action
IGF-1 exerts its biological actions primarily by binding to the type I insulin-like growth factor receptor (IGF-1R), activating intracellular signaling cascades such as the PI3K/Akt pathway.
03
Biological functions
Growth promotionCell proliferationInhibition of apoptosisDNA synthesis stimulationMetabolic regulation
04
Disease associations
CancerDuchenne muscular dystrophyMuscle atrophyDevelopmental defects
05
Safety considerations
Overexpression or hyperactivation can contribute to cancer progression.Potential for side effects due to systemic growth promotion.
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