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Target intelligence / Profile preview
Insulin-like Growth Factor 1 Receptor (IGF-1R)
- Target
- IGF-1R
- Molecular classification
- Receptor, Transmembrane receptor, Tyrosine kinase receptor
01
Overview
The Insulin-like Growth Factor 1 Receptor (IGF-1R) is a transmembrane receptor tyrosine kinase that mediates the effects of IGF-1, IGF-2 and insulin. Upon ligand binding, the receptor undergoes autophosphorylation, activating downstream signaling cascades such as the PI3K/Akt pathway, promoting cell survival, proliferation, metabolism regulation, neuroprotection, and neuroregeneration. Dysregulation of IGF-1R is implicated in various human cancers, making it an important target for anti-cancer drug development.
02
Mechanism of action
Small molecule antagonists or monoclonal antibodies targeting the IGF-1R pathway are under investigation.
03
Biological functions
Signal transductionCell proliferationCell survival/anti-apoptosisRegulation of differentiationSomatic growthMetabolism regulationNeuroprotectionNeuroregeneration
04
Disease associations
Cancer
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