Insulin-like growth factor 1 receptor messenger RNA (IGF1R mRNA)

Insulin-like growth factor 1 receptor (IGF1R) mRNA is the messenger RNA transcript that encodes the IGF1R protein, a critical transmembrane tyrosine kinase receptor involved in mediating the effects of insulin-like growth factors 1 and 2 (NCBI Gene: 3480). This mRNA serves as the essential template for the synthesis of the receptor, which plays a pivotal role in cell proliferation, survival, and transformation (PubMed: 15585444). In many human cancers, IGF1R mRNA is overexpressed, contributing to tumor growth, metastasis, and resistance to conventional therapies like chemotherapy and radiation (PubMed: 12479709). Targeting the mRNA directly using antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) allows for the specific downregulation of the receptor protein, potentially offering higher selectivity than small molecule inhibitors that may cross-react with the insulin receptor (PubMed: 20603254). Therapeutic candidates like ATL1101 have been developed to exploit this mechanism for treating conditions such as prostate cancer and psoriasis (Antisense Therapeutics).

Other names

IGF-I receptor mRNACD221 mRNAInsulin-like growth factor I receptor mRNA

Antisense inhibition of translation and RNase H-mediated mRNA degradation