Insulin-like growth factor 1 receptor messenger RNA (IGF-1R mRNA) (IGF-1R mRNA)

Insulin-like growth factor 1 receptor (IGF-1R) messenger RNA is the genetic template responsible for the synthesis of the IGF-1R protein, a key mediator of cell growth, transformation, and survival (PubMed: 12467225). In many cancers, the overexpression of IGF-1R mRNA leads to an abundance of the receptor, which promotes tumor progression and resistance to apoptosis (PubMed: 10491401). Targeting the mRNA directly using antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) offers a method to downregulate the entire IGF-1R signaling pathway at its source. This approach is particularly relevant in conditions like glioblastoma and prostate cancer, where traditional inhibitors have faced challenges (ClinicalTrials.gov: NCT02507583). However, therapeutic intervention must be carefully managed to avoid interfering with the closely related insulin receptor, which could lead to metabolic complications such as hyperglycemia.

Other names

IGF1R mRNAInsulin-like growth factor I receptor mRNACD221 mRNAJTK13 mRNA

Antisense oligonucleotides and RNA interference (RNAi) molecules bind to the IGF-1R mRNA sequence, leading to its degradation via RNase H or the RNA-induced silencing complex (RISC), thereby preventing the translation of the IGF-1R protein.