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Target intelligence / Profile preview
Insulin-like Growth Factor 2 (IGF2)
- Target
- IGF2
- Molecular classification
- Growth Factor, Hormone
01
Overview
Insulin-like growth factor 2 (IGF2) is a protein hormone structurally similar to insulin. It plays a critical role in fetal development, cell proliferation, differentiation, migration, and survival. IGF2 is primarily active during embryonic and fetal stages but continues to have functions in adult tissues. Dysregulation or loss of imprinting at the IGF2 locus has been linked to overgrowth syndromes and various cancers.
02
Mechanism of action
Agonism of IGF1R, IR-A
03
Biological functions
Cell proliferationDifferentiationMigrationCell survivalFetal growthMetabolic regulation
04
Disease associations
Overgrowth syndromesCancerHypoglycemiaCardiovascular disease
05
Safety considerations
Potential for promoting tumor growthHypoglycemiaCardiovascular risks
06
Biomarkers
IGF2 expression levelsLoss of imprinting (LOI) at the IGF2 locusMethylation status at the IGF2/H19 locus
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