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Target intelligence / Profile preview
Insulin-like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1)
- Target
- IGF2BP1
- Molecular classification
- RNA-binding protein
01
Overview
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an RNA-binding protein that plays a key role in post-transcriptional regulation. It binds to specific mRNAs, most notably the insulin-like growth factor 2 (IGF2) transcript, and modulates their localization, stability, and translation. IGF2BP1 is highly expressed during embryogenesis and is often re-expressed or upregulated in various cancers, promoting tumorigenesis. It also plays a role in intestinal barrier function and reproductive biology.
- Other names
- CRD-BPCRDBPIMP-1IMP1VICKZ1ZBP1
02
Mechanism of action
Not applicable, direct inhibitors not yet readily available, targeting the RNA binding process to target mRNAs
03
Biological functions
Regulation of cell growth and metabolismControl over cell migration and invasionRegulation of mRNA stabilityRegulation of mRNA translationmRNA transportEpithelial barrier function
04
Disease associations
CancerIntestinal DisordersReproductive Disorders
05
Safety considerations
Broad impact on mRNA regulation could lead to off-target effectsInhibition of IGF2BP1 in normal tissues may disrupt essential biological processes
06
Biomarkers
IGF2BP1 expression levels in tumor tissue
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