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Target intelligence / Profile preview
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
- Target
- IGF2BP2
- Molecular classification
- RNA-binding protein, Oncofetal protein
01
Overview
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2, also known as IMP2) is a member of the IGF2 mRNA-binding protein family that contains four KH (K-homology) and two RRM (RNA recognition motif) domains[1][3][7]. IGF2BP2 binds to the 5'-UTR of IGF2 and other transcripts, regulating their localization, stability, and translation, which influences diverse biological processes—especially during embryogenesis, metabolism, and tumorigenesis[2][4][5]. Dysregulation of IGF2BP2 has been implicated as a genetic risk factor for type 2 diabetes and as a facilitator of cancer cell proliferation and metastasis. Recent studies suggest its potential as a therapeutic and biomarker target, but no direct-acting drugs are currently available.
- Other names
- IMP2IGF-II mRNA-binding protein 2VICKZ2p62
02
Mechanism of action
Not applicable (no approved drugs; experimental knockdown/inhibition impairs mRNA binding and stability, affecting downstream gene expression[6])
03
Biological functions
RNA localizationRNA stabilityRegulation of mRNA translationCell proliferationEmbryonic developmentMetabolic regulation
04
Disease associations
Type 2 diabetes mellitusCancer (including testicular cancer, carcinogenesis broadly)Metabolic syndromesInsulin resistance
05
Safety considerations
Potential for off-target effects if targeting IGF2BP2 systemically, given its roles in embryonic development and metabolismtheoretical risk for impact on normal stem cell function and metabolic homeostasis[2][6]
06
Biomarkers
Type 2 diabetes genetic susceptibility (certain IGF2BP2 SNPs)possible prognostic biomarker in cancer and diabetes[4][5][6]
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