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Target intelligence / Profile preview
Insulin-like growth factor 2 mRNA-binding protein 2 antisense RNA 1 (IGF2BP2-AS1)
- Target
- IGF2BP2-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-coding RNA
01
Overview
Insulin-like growth factor 2 mRNA-binding protein 2 antisense RNA 1 (IGF2BP2-AS1) is a long non-coding RNA transcribed from the antisense strand of the IGF2BP2 gene region. It is predominantly localized in the cytoplasm of cancer cells and has been shown to promote cell proliferation, migration, and suppress apoptosis, particularly in oral squamous cell carcinoma[2]. Elevated expression of IGF2BP2-AS1 is associated with poor patient survival and may regulate tumor progression by modulating critical pathways such as Wnt/β-catenin signaling. While not a direct therapeutic target as of current knowledge, IGF2BP2-AS1 may function as a novel molecular marker and a potential candidate for future RNA-targeted cancer therapies[2][5].
- Other names
- IGF2BP2 antisense RNA 1C3orf65FLJ32900IGF2BP2-AS1IGF2BP2 antisense gene protein 1
02
Biological functions
Regulation of cell proliferationRegulation of apoptosisPromotion of migration and cell cycle progressionLikely regulation of gene expression at a post-transcriptional level
03
Disease associations
Cancer (including oral squamous cell carcinoma and lung squamous cell carcinoma)Possibly prognostic for survival in specific cancers
04
Biomarkers
High IGF2BP2-AS1 expression is associated with poor prognosis in oral squamous cell carcinoma and lung cancer; may serve as a prognostic biomarker
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