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Target intelligence / Profile preview
Insulin-like Growth Factor 2 Receptor (IGF2R)
- Target
- IGF2R
- Molecular classification
- Receptor, Transmembrane Glycoprotein
01
Overview
The insulin-like growth factor 2 receptor (IGF2R), also known as the cation-independent mannose-6-phosphate receptor (CI-MPR), is a multifunctional transmembrane glycoprotein. It binds both IGF-II and mannose-6-phosphate-tagged proteins. Its functions include clearing IGF-II from the cell surface to attenuate its signaling and transporting lysosomal acid hydrolase precursors. It primarily acts as a tumor suppressor by sequestering excess IGF-II.
- Other names
- Cation-independent mannose–6–phosphate receptorCI-MPRM6P/IGFIIR
02
Mechanism of action
Sequesters and clears IGF-II from the cell surface, preventing excessive mitogenic stimulation. Transports lysosomal acid hydrolase precursors.
03
Biological functions
Ligand BindingRegulation of Growth Factor SignalingLysosomal Enzyme TraffickingIGF-II clearanceMannose-6-phosphate protein transport
04
Disease associations
Tumor SuppressionCancer
05
Safety considerations
Imbalances or loss-of-function mutations may contribute to tumorigenesis.
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