Insulin-like growth factor-binding protein 1 (IGFBP-1)

Insulin-like growth factor-binding protein 1 (IGFBP-1) is a secreted protein that binds insulin-like growth factors I and II (IGF-1 and IGF-2) in circulation, thereby regulating their half-life and bioavailability and modulating their interactions with cellular receptors. IGFBP-1 is encoded by the IGFBP1 gene, is also known as placental protein 12, and possesses an IGFBP domain as well as a thyroglobulin type-I domain. It plays a critical role in various cellular processes including migration, proliferation, differentiation, and apoptosis, both by modulating IGF action and through IGF-independent interactions with integrins via its RGD motif. IGFBP-1 is implicated in several physiological and pathological states, including cancer, cardiovascular disease, metabolic syndrome, and pregnancy-related disorders[4][5][6].

Other names

IBP-1IGF-binding protein 1Placental protein 12PP12

Inhibition of IGF signaling by sequestration of IGFs, preventing their interaction with IGF receptors. Modulation of integrin signaling via RGD motif, affecting cell adhesion and migration.