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Insulin-like growth factor-binding protein 7 antisense RNA 1 (IGFBP7-AS1)

Target: IGFBP7-AS1
Molecular classification: Long non-coding RNA (lncRNA), Natural antisense transcript (NAT), Other

Overview

IGFBP7-AS1 is a long non-coding RNA transcribed antisense to the IGFBP7 gene. It acts as a natural antisense transcript, partially complementary to IGFBP7 exon 1, and positively regulates IGFBP7 mRNA stability by forming sense–antisense RNA duplexes. IGFBP7-AS1 is enriched in the cytoplasm and enhances the expression of IGFBP7, a gene involved in cell adhesion, proliferation, and differentiation. Functional studies show IGFBP7-AS1 promotes odontogenic differentiation in dental stem cells and regulates viability and invasion of glioma cells, with high expression being a negative prognostic factor in glioblastoma. IGFBP7-AS1’s biological effects appear to be mediated chiefly by its regulatory impact on IGFBP7, rather than any independent protein-coding function. There is no evidence that IGFBP7-AS1 is a direct drug target, though its role in cancer and tissue engineering identifies it as a potential therapeutic or biomarker molecule.

Other names: IGFBP7 antisense RNA 1IGFBP7-AS1

Biological functions

Positive regulation of IGFBP7 mRNA stability and expression (post-transcriptional regulation)Regulation of odontogenic differentiation in stem cells from human exfoliated deciduous teeth (SHED)Regulation of tumor cell viability, migration, and invasion (notably in glioblastoma/glioma)

Disease associations

Cancer (implicated in glioblastoma and potentially other tumor types)Dental tissue engineering (regulation of odontogenesis in SHED)Other (potential as a prognostic biomarker)

Biomarkers

Prognostic biomarker in glioblastoma (high IGFBP7-AS1 expression associated with poor prognosis)Part of multi-lncRNA signatures for glioma outcome prediction

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