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Target intelligence / Profile preview
Insulin-like Growth Factor Binding Protein II (IGFBP-2)
- Target
- IGFBP-2
- Molecular classification
- Insulin-Like Growth Factor Binding Proteins
01
Overview
Insulin-like growth factor binding protein 2 (IGFBP-2) is a member of the IGFBP family that binds insulin-like growth factors I and II (IGF-I and IGF-II) with high affinity, regulating their bioavailability and activity. It can also influence cellular processes independently from its interaction with insulin-like growth factors. Dysregulation implicated in cancer biology.
02
Mechanism of action
Modulates bioavailability and activity of IGF-I and IGF-II; IGF-independent actions modulating gene expression related to proliferation, adhesion/migration, apoptosis.
03
Biological functions
Regulation of IGF activityCell proliferationCell differentiationCell survivalCell migrationApoptosis
04
Disease associations
CancerMetabolic disorders
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