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Target intelligence / Profile preview
Insulin-like Growth Factor I (IGF-1)
- Target
- IGF-1
- Molecular classification
- Protein hormone, Peptide hormone, Growth Factor
01
Overview
Insulin-like growth factor I mediates many effects attributed to growth hormone. It plays an important role throughout life—from promoting childhood linear bone/tissue expansion to supporting adult anabolic processes—and has broad implications for metabolic health.
- Other names
- somatomedin CIGFsulfation factornonsuppressible insulin-like activityNSILA
02
Mechanism of action
Binding to IGF1R, activating MAP kinase and PI3K pathways to regulate cell survival/growth/proliferation/differentiation
03
Biological functions
Promotion of normal bone and tissue growth and developmentAnabolic effects such as muscle hypertrophy and tissue repairRegulation of cell proliferationInhibition of apoptosis/cell deathModulation of glucose transportRegulation of neural developmentNeurogenesisMyelinationSynaptogenesisDendritic branchingNeuroprotection
04
Disease associations
AcromegalyLaron SyndromeType II DiabetesCardiovascular diseaseCancerHearing loss
05
Safety considerations
High levels associated with increased cancer riskAltered levels linked to cardiovascular disease
06
Interacting drugs
Mecasermin
07
Biomarkers
Serum IGF-I levels for diagnosis and monitoring of GH-related disorders
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