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Target intelligence / Profile preview
Insulin-like Growth Factor II (None)
- Target
- None
- Molecular classification
- Peptide hormone, Growth factor
01
Overview
Insulin-like growth factor II (IGF-II) is a protein hormone structurally similar to insulin and is a key member of the IGF system. It plays a critical role in regulating growth, development, metabolism, and cell survival. IGF-II acts primarily through the IGF-1R and IR-A receptors. Dysregulation of IGF2 and its signaling pathways are implicated in developmental disorders, cancers, and metabolic diseases. The mannose 6-phosphate receptor acts as a scavenger/antagonist for IGF-II.
- Other names
- IGF-IIIGF2
02
Mechanism of action
Modulation of IGF-1R and IR-A signaling pathways
03
Biological functions
Growth promotionCell proliferationCell differentiationCell migrationCell survivalMetabolic regulationNeurogenesisStem cell maintenanceAdipose tissue regulationMuscle differentiationOvarian folliculogenesisProgesterone secretion
04
Disease associations
Overgrowth syndromesBeckwith-Wiedemann syndromeSilver-Russell syndromeBreast cancerColon cancerLung cancerCardiovascular diseaseMetabolic disease
05
Safety considerations
Potential for tumorigenesis with overexpressionComplex role in apoptosis regulationImpact on cardiovascular and metabolic health
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