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Target intelligence / Profile preview
Lung Cancer-Associated Antigen L523S (L523S)
- Target
- L523S
- Molecular classification
- RNA-binding protein, Oncofetal protein
01
Overview
Lung cancer-associated antigen L523S (L523S), also known as KOC or IMP-3, is an oncofetal RNA-binding protein highly expressed in non-small cell lung cancer (NSCLC). Its restricted expression in normal adult tissues, compared to high expression in NSCLC subtypes, makes it a promising target for immunotherapeutic interventions. It is being investigated as a potential target for vaccine-based immunotherapy.
- Other names
- KOCIMP-3K homology domain-containing protein over-expressed in cancerInsulin-like growth factor-II mRNA-binding protein 3
02
Mechanism of action
Currently under investigation; recombinant DNA-L523S vaccines aim to elicit anti-tumor immune responses.
03
Biological functions
RNA bindingRegulation of gene expressionCell proliferationTumorigenesis
04
Disease associations
CancerNon-small cell lung carcinoma (NSCLC)Squamous cell carcinomaAdenocarcinoma
05
Safety considerations
Potential for off-target effects (though limited due to restricted expression)Risk of autoimmunity (though considered low due to minimal expression in adult tissues)
06
Biomarkers
Diagnostic marker for NSCLCPredictive marker for response to immunotherapy
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