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Target intelligence / Profile preview
Insulin-like growth factor type 1 receptor (IGF-1R)
- Target
- IGF-1R
- Molecular classification
- Receptor, Transmembrane receptor, Tyrosine kinase
01
Overview
Insulin-like growth factor type 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase that mediates the actions of IGF-1, IGF-2, and, to a lesser extent, insulin. Upon ligand binding, the receptor undergoes autophosphorylation, triggering downstream signaling pathways that regulate cell proliferation, survival, differentiation, and metabolism. It plays a crucial role in somatic growth and protects cells from apoptosis. Dysregulation or overexpression is linked to tumorigenesis and cancer cell survival.
- Other names
- IGF‑IR
02
Mechanism of action
Targeting IGF-1R to inhibit tumor cell survival/proliferation and promote apoptosis.
03
Biological functions
Signal transductionCell proliferationCell survivalCell differentiationMetabolismSomatic growthAnti-apoptosis
04
Disease associations
CancerTumorigenesis
05
Safety considerations
Dysregulation or overexpression contributes to malignant transformation in various cancers.
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