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Target intelligence / Profile preview
Insulin Receptor (IR)
- Target
- IR
- Molecular classification
- Receptor, Receptor Tyrosine Kinase
01
Overview
The insulin receptor (IR) is a transmembrane protein belonging to the receptor tyrosine kinase family. It is primarily responsible for mediating the effects of insulin, a key hormone in regulating glucose homeostasis, as well as playing roles in growth and metabolism. The IR is found on the surface of most cells throughout the human body.
- Other names
- INSRCD220Insulin Receptor Substrate 1IR
02
Mechanism of action
Insulin binds to the extracellular domain, triggering autophosphorylation of the intracellular kinase domain and subsequent activation of downstream signaling pathways (e.g., PI3K/AKT/mTOR and MAPK).
03
Biological functions
Signal transductionGlucose uptake regulationLipid metabolism controlCell growthCell differentiationCell proliferation
04
Disease associations
Diabetes mellitusInsulin resistance syndromesCancer
05
Safety considerations
Hypoglycemia (with insulin therapy)Insulin resistance
06
Interacting drugs
Insulin
3 more in the full profile.
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