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Target intelligence / Profile preview
Insulin Receptor A (IR-A)
- Target
- IR-A
- Molecular classification
- Receptor, Receptor tyrosine kinase
01
Overview
Insulin Receptor A (IR-A) is a transmembrane receptor tyrosine kinase and one of two isoforms of the insulin receptor. Generated by alternative splicing of the INSR gene (excluding exon 11), IR-A exhibits higher affinity for IGF-II and is predominantly expressed during fetal development and in certain cancer cells. It mediates both metabolic and mitogenic responses to insulin and related growth factors.
02
Mechanism of action
Tyrosine kinase activation; downstream signaling via PI3K/Akt and MAPK pathways.
03
Biological functions
Signal transductionGlucose uptake regulationLipid metabolism regulationProtein synthesis regulationCell growthCell proliferationCell differentiationSurvival/apoptosis decisions
04
Disease associations
Diabetes mellitusCancer
05
Safety considerations
Potential for tumorigenesis due to enhanced mitogenic signaling
06
Interacting drugs
Insulin
2 more in the full profile.
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