Target intelligence / Profile preview

Insulin Receptor Kinase (IR)

Target: IR
Molecular classification: Receptor Tyrosine Kinase, Receptor

Overview

The insulin receptor kinase, commonly referred to as the insulin receptor (IR), is a transmembrane protein belonging to the receptor tyrosine kinase (RTK) family. It is primarily responsible for mediating the cellular effects of insulin, a key hormone in regulating glucose and lipid metabolism.

Other names: Insulin ReceptorINSR

Mechanism of action

Agonist; activation of intracellular signaling pathways via tyrosine kinase activity.

Biological functions

Signal transductionGlucose metabolism regulationLipid metabolism regulationProtein synthesisCell growth/differentiationCell survival

Disease associations

Diabetes mellitusCancer

Safety considerations

HypoglycemiaInsulin resistance

Interacting drugs

Insulin

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