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Target intelligence / Profile preview
Insulin Receptor Substrate 1 (IRS1)
- Target
- IRS1
- Molecular classification
- Adaptor protein, Scaffolding protein
01
Overview
Insulin receptor substrate 1 (IRS-1) is a key intracellular signaling adaptor protein that mediates insulin and IGF-1 signaling. It is activated by tyrosine phosphorylation upon receptor stimulation, which creates docking sites for SH2 domain-containing proteins, leading to activation of downstream pathways like PI3K/Akt and MAPK/ERK. Serine/threonine phosphorylation negatively regulates IRS-1 function, contributing to insulin resistance in conditions like obesity and type II diabetes.
- Other names
- IRS-1
02
Mechanism of action
Modulation of tyrosine/serine phosphorylation to enhance or inhibit downstream signaling pathways (PI3K/Akt, MAPK/ERK)
03
Biological functions
Signal transductionGlucose metabolismCell growthCell proliferationInsulin signalingIGF-1 signaling
04
Disease associations
Type II diabetes mellitusInsulin resistanceObesityMetabolic syndrome
05
Safety considerations
Inhibition of IRS1 function can lead to insulin resistance and metabolic disorders.Over-activation of downstream signaling pathways can promote cell proliferation and potentially cancer.
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