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Target intelligence / Profile preview
Insulin Receptor Substrate 2 (IRS2)
- Target
- IRS2
- Molecular classification
- Cytoplasmic signaling adaptor protein
01
Overview
IRS2 is a key cytoplasmic signaling molecule that mediates the effects of insulin, insulin-like growth factor 1 (IGF1), and other cytokines. It acts as a molecular adaptor between various receptor tyrosine kinases—such as the insulin receptor and IGF1R—and downstream effectors in multiple cellular pathways. Upon stimulation by its upstream receptors, IRS2 is phosphorylated on tyrosine residues, enabling it to recruit SH2 domain-containing proteins and propagate intracellular signals essential for metabolic regulation, cell growth, survival, proliferation, and differentiation. Dysregulation of IRS2 is implicated in diseases such as type 2 diabetes, PCOS and cancer.
- Other names
- IRS-2
02
Biological functions
Signal transductionGlucose homeostasisEnergy balanceCell growthCell survivalCell proliferationCell differentiationBone metabolism
03
Disease associations
Type 2 Diabetes MellitusPolycystic Ovary SyndromeCancerOsteopenia
04
Safety considerations
Aberrant activation can contribute to tumorigenesisComplex role in various tissues requires careful consideration for targeted therapies
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