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Target intelligence / Profile preview
Leucyl/cystinyl Aminopeptidase (LNPEP)
- Target
- LNPEP
- Molecular classification
- Enzyme, Metallopeptidase, Type II transmembrane protein
01
Overview
Leucyl/cystinyl aminopeptidase (LNPEP) is a zinc-dependent metalloaminopeptidase that cleaves N-terminal amino acids, especially leucine and cysteine, from peptide substrates. It degrades several peptide hormones including oxytocin, vasopressin, angiotensin III, lys-bradykinin, met-enkephalin, and dynorphin A. It plays important roles in hormone regulation, antigen processing, blood pressure regulation, and signal transduction. It is a type II transmembrane protein found in multiple cellular compartments.
- Other names
- Cystinyl aminopeptidaseInsulin-regulated membrane aminopeptidase (IRAP)Insulin-responsive aminopeptidaseOTASEOxytocinaseP-LAP (Placental leucine aminopeptidase)
02
Mechanism of action
Hydrolyzes N-terminal amino acids, particularly leucine and cysteine, from peptides and proteins.
03
Biological functions
Peptide catabolic process/proteolysisHormone regulationAntigen processing and presentationBlood pressure regulationSignal transduction
04
Disease associations
CancerPregnancy complications (potential)Hypertension (potential)
05
Biomarkers
Prognostic biomarker in ovarian cancer
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