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Target intelligence / Profile preview
Insulin Resistance Pathway via PI3K-AKT Signaling (PI3K-AKT Insulin Resistance Pathway)
- Target
- PI3K-AKT Insulin Resistance Pathway
- Molecular classification
- Signaling pathway
01
Overview
The insulin resistance pathway via the PI3K-AKT signaling pathway is a central molecular cascade that mediates the effects of insulin on glucose and lipid metabolism. This pathway is crucial for maintaining glucose homeostasis, and its dysfunction is a key contributor to metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. Impairment or inhibition of any step within this signaling cascade leads to reduced cellular response to insulin resulting in decreased glucose uptake into cells, increased hepatic gluconeogenesis, and enhanced lipolysis with elevated free fatty acids.
- Other names
- Insulin signaling pathwayPI3K/AKT pathway in insulin resistanceInsulin resistance signaling cascade
02
Mechanism of action
Drugs under investigation aim at restoring/enhancing PI3K/AKT activity.
03
Biological functions
Glucose uptake regulationGlycogen synthesisLipid metabolism regulationProtein synthesis regulationCell survivalInsulin signaling
04
Disease associations
Insulin resistanceType 2 diabetes mellitusObesityMetabolic syndromeAlzheimer's disease (implicated)
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