Insulin Sensitivity

Insulin sensitivity describes how well your body’s cells respond to the hormone’s signal—a central determinant in healthy metabolism. It is not a molecule itself but rather a physiological property reflecting molecular interactions at the cellular level involving key signaling pathways downstream from the activated INSR receptor complex.

Other names

Insulin responsivenessCellular response to insulin

Varies depending on the drug. Metformin reduces hepatic glucose production and increases insulin sensitivity. TZDs activate PPARγ, increasing insulin sensitivity. Sulfonylureas stimulate insulin secretion. Insulin supplements deficient endogenous production.