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Integral membrane protein 2C (ITM2C)
- Target
- ITM2C
- Molecular classification
- Transmembrane protein, BRICHOS domain-containing protein, Other (not a GPCR, enzyme, ion channel, transporter, or typical receptor)
01
Overview
Integral membrane protein 2C is a 30.5 kDa BRICHOS domain-containing transmembrane protein involved in the negative regulation of amyloid-beta peptide production, likely by inhibiting amyloid precursor protein (APP) access to alpha- and beta-secretases. This function is relevant to Alzheimer’s disease pathology. ITM2C is also implicated in processes such as neuron differentiation, negative regulation of neuron projection development, and may play a role in TNF-induced cell death. Clinically, ITM2C serves as a prognostic marker for select cancers. It is primarily expressed in the brain and certain other tissues
- Other names
- CT-BRI3BRI3hucep-14NPD018PSEC0047E25hRPC.1050_D_4ITM3BRICD2CCerebral protein 14Transmembrane protein BRI3BRICHOS domain containing 2CE25C
02
Biological functions
Negative regulation of amyloid-beta peptide production (inhibits processing of APP, which impacts Alzheimer’s pathology)Neuron differentiationNegative regulation of neuron projection developmentCell death (potential involvement in TNF-induced apoptosis)Positive regulation of extrinsic apoptotic signaling pathway
03
Disease associations
Neurodegenerative disease (implicated via amyloid-beta regulation, e.g., Alzheimer’s disease)Cancer (prognostic biomarker in some tumors, e.g., renal clear cell carcinoma, rectum adenocarcinoma)
04
Biomarkers
Prognostic marker for kidney renal clear cell carcinomaPrognostic marker for rectum adenocarcinoma
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